類胰島素生長因子(insulin-like growth factor)
-是一個內含3個雙硫鍵的單一多胜肽(peptide),具有70個氨基酸分子量為
7,649 daltons,結構上與IGF-2及Insulin同源。
-IGF-1常和 IGF
結合蛋白及酸化次分子形成立體結構的大分子在血液中循
環。
-在人體內其生成受到生長激素與營養獲取的刺激。
-在人體血液中 IGF-1的濃度在初生時期幾近於零,但隨幼兒期逐
漸增加到青春期時上升到高峰,直到40歲以後再逐漸下降。
-母親在懷孕時其濃度也會增加,因此在診斷生長狀況異常時
IGF-1是很好的生長激素 (growth hormone)指標。
低IGF-1值: 顯示生長激素缺乏症並且需要進一步的檢測其分泌量是否不正常。
測定 IGF-1也同時可用來作為評量營養狀態變
化的指標。
運送: 採檢後1小時內以冰浴方式送
方法: 化學冷光免疫分析法(One-step sandwich chemiluminescent immunometric assay)
Neonatal:
1-7
days 95% percentile: 26 ng/mL、
8-15 days 95% percentile:41 ng/mL;
1
Age,(year):55-327(Central 95% Range (ng/mL);
2 Age,(year):51-303(Central
95% Range (ng/mL);
3 Age,(year):49-289(Central 95% Range (ng/mL);
4
Age,(year):49-283(Central 95% Range (ng/mL);
5 Age,(year):50-286(Central
95% Range (ng/mL);
6 Age,(year):52-297(Central 95% Range (ng/mL);
7
Age,(year):57-316(Central 95% Range (ng/mL);
8 Age,(year):64-345(Central
95% Range (ng/mL);
9 Age,(year):74-388(Central 95% Range (ng/mL);
10
Age,(year):88-452(Central 95% Range (ng/mL);
11
Age,(year):111-551(Central 95% Range (ng/mL);
12
Age,(year):143-693(Central 95% Range (ng/mL);
13
Age,(year):183-850(Central 95% Range (ng/mL);
14
Age,(year):220-972(Central 95% Range (ng/mL);
15
Age,(year):237-996(Central 95% Range (ng/mL);
16
Age,(year):226-903(Central 95% Range (ng/mL);
17
Age,(year):193-731(Central 95% Range (ng/mL);
18
Age,(year):163-584(Central 95% Range (ng/mL);
19
Age,(year):141-483(Central 95% Range (ng/mL);
20
Age,(year):127-424(Central 95% Range (ng/mL);
21-25
Age,(year):16-358(Central 95% Range (ng/mL);
26-30
Age,(year):117-329(Central 95% Range (ng/mL);
31-35
Age,(year):115-307(Central 95% Range (ng/mL);
36-40
Age,(year):109-284(Central 95% Range (ng/mL);
41-45
Age,(year):101-267(Central 95% Range (ng/mL);
46-50
Age,(year):94-252(Central 95% Range (ng/mL);
51-55
Age,(year):87-238(Central 95% Range (ng/mL);
56-60
Age,(year):81-225(Central 95% Range (ng/mL);
61-65
Age,(year):75-212(Central 95% Range (ng/mL);
66-70
Age,(year):69-200(Central 95% Range (ng/mL);
71-75
Age,(year):64-188(Central 95% Range (ng/mL);
76-80
Age,(year):59-177(Central 95% Range (ng/mL);
81-85
Age,(year):55-166(Central 95% Range (ng/mL)
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